![]() Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs)-protein-coupled receptors. ![]() SynthesisĬyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. Human mutation data reported.When heated to decomposition it emits toxic fumes ofPOx and NOx. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis. cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). ![]() Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways. General DescriptionĬyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. It is a conjugate acid of a 3',5'-cyclic AMP(1-). It is an adenyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. DefinitionĬhEBI: Cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. UsesĬAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Slightly soluble in water, almost insoluble in ethanol or ether. White crystalline or Pale yellow powder odorless.
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